Details

Autor(en) / Beteiligte

• Shafqat, Areez
• Arabi, Tarek Z.
• Sabbah, Belal N.
• Abdulkader, Humzah S.
• Shafqat, Shameel
• Razak, Adhil
• Kashir, Junaid
• Alkattan, Khaled
• Yaqinuddin, Ahmed

Titel

Understanding COVID-19 Vaccines Today: Are T-cells Key Players?

Ist Teil von

• Vaccines (Basel), 2022-06, Vol.10 (6), p.904

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has heavily mutated since the beginning of the coronavirus-2019 (COVID-19) pandemic. In this regard, the so-called variants of concern (VOCs) feature mutations that confer increased transmissibility and evasion of antibody responses. The VOCs have caused significant spikes in COVID-19 cases, raising significant concerns about whether COVID-19 vaccines will protect against current and future variants. In this context, whereas the protection COVID-19 vaccines offer against the acquisition of infection appears compromised, the protection against severe COVID-19 is maintained. From an immunologic standpoint, this is likely underpinned by the maintenance of T-cell responses against VOCs. Therefore, the role of T-cells is essential to understanding the broader adaptive immune response to COVID-19, which has the potential to shape public policies on vaccine protocols and inform future vaccine design. In this review, we survey the literature on the immunology of T-cell responses upon SARS-CoV-2 vaccination with the current FDA-approved and Emergency Use Authorized COVID-19 vaccines.