Details

Autor(en) / Beteiligte

• Ribeiro-Parenti, Lara
• Jarry, Anne-Charlotte
• Cavin, Jean-Baptiste
• Willemetz, Alexandra
• Le Beyec, Johanne
• Sannier, Aurélie
• Benadda, Samira
• Pelletier, Anne-Laure
• Hourseau, Muriel
• Léger, Thibaut
• Morlet, Bastien
• Couvelard, Anne
• Anini, Younes
• Msika, Simon
• Marmuse, Jean-Pierre
• Ledoux, Sévérine
• Le Gall, Maude
• Bado, André

Titel

Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells

Ist Teil von

• Nature communications, 2021-01, Vol.12 (1), p.110-110, Article 110

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.