Brain sciences, 2022-06, Vol.12 (6), p.790
2022
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- Autor(en) / Beteiligte
- Titel
- Vitamin D Status and Parkinson’s Disease
- Ist Teil von
- Brain sciences, 2022-06, Vol.12 (6), p.790
- Ort / Verlag
- Basel: MDPI AG
- Erscheinungsjahr
- 2022
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Parkinson’s disease (PD) is a complex and progressive neurodegenerative disease, characterized by resting tremor, rigidity, slowness of movement, and postural instability. Furthermore, PD is associated with a wide spectrum of non-motor symptoms that add to overall disability. In recent years, some investigations, from basic science to clinical applications, have focused on the role of vitamin D in PD, often with controversial findings. Vitamin D has widespread effects on several biological processes in the central nervous system, including neurotransmission in dopaminergic neural circuits. Various studies have recorded lower levels of vitamin D in PD patients than in healthy controls. Low vitamin D status has also been correlated with the risk for PD and motor severity, whereas less is known about the effects vitamin D has on cognitive function and other non-motor symptoms. This review aims to better characterize the correlation between vitamin D and PD, clarify the role of vitamin D in PD prevention and treatment, and discuss avenues for future research in this field.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2076-3425eISSN: 2076-3425DOI: 10.3390/brainsci12060790Titel-ID: cdi_doaj_primary_oai_doaj_org_article_8ae754b50e78446bb48d029da6791a67
- Format
- –
- Schlagworte
- Alzheimer's disease, Central nervous system, Cognitive ability, Dopamine receptors, hypovitaminosis D, Metabolism, Metabolites, Movement disorders, Neural networks, Neurodegenerative diseases, Neurotransmission, Parkinson's disease, Pathophysiology, Review, Tremor, Vitamin D, vitamin D deficiency, vitamin D insufficiency, vitamin D receptor (VDR) polymorphisms, Vitamin deficiency