Details

Autor(en) / Beteiligte

• Carneiro, Vanessa Cristine de Souza
• Alves-Leon, Soniza Vieira
• Sarmento, Dmitry José de Santana
• Coelho, Wagner Luis da Costa Nunes Pimentel
• Moreira, Otacilio da Cruz
• Salvio, Andreza Lemos
• Ramos, Carlos Henrique Ferreira
• Ramos Filho, Carlos Henrique Ferreira
• Marques, Carla Augusta Barreto
• da Costa Gonçalves, João Paulo
• Leon, Luciane Almeida Amado
• de Paula, Vanessa Salete

Titel

Herpesvirus and neurological manifestations in patients with severe coronavirus disease

Ist Teil von

• Virology journal, 2022-06, Vol.19 (1), p.101-101, Article 101

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms. We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method. Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034). The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.