Details

Autor(en) / Beteiligte

• Werneck-Silva, A L
• Sipahi, A M
• Damião, A O
• Buchpigue, C A
• Iriya, K
• Laudanna, A A

Titel

Intestinal permeability in strongyloidiasis

Ist Teil von

• Brazilian journal of medical and biological research, 2001-03, Vol.34 (3), p.353-357

Ort / Verlag

Brazil: Associação Brasileira de Divulgação Científica

Erscheinungsjahr

2001

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• The objective of the present study was to assess intestinal permeability in patients with infection caused by Strongyloides stercoralis. Twenty-six patients (16 women and 10 men), mean age 45.9, with a diagnosis of strongyloidiasis were evaluated. For comparison, 25 healthy volunteers (18 women and 7 men), mean age 44.9, without digestive disorders or intestinal parasites served as normal controls. Intestinal permeability was measured on the basis of urinary radioactivity levels during the 24 h following oral administration of chromium-labeled ethylenediaminetetraacetic acid ((51)Cr-EDTA) expressed as percentage of the ingested dose. The urinary excretion of (51)Cr-EDTA was significantly reduced in patients with strongyloidiasis compared to controls (1.60 +/- 0.74 and 3.10 +/- 1.40, respectively, P = 0.0001). Intestinal permeability is diminished in strongyloidiasis. Abnormalities in mucus secretion and intestinal motility and loss of macromolecules could explain the impaired intestinal permeability.