Details

Autor(en) / Beteiligte

• Oh, Gabriel
• Ebrahimi, Sasha
• Carlucci, Matthew
• Zhang, Aiping
• Nair, Akhil
• Groot, Daniel E
• Labrie, Viviane
• Jia, Peixin
• Oh, Edward S
• Jeremian, Richie H
• Susic, Miki
• Shrestha, Tenjin C
• Ralph, Martin R
• Gordevičius, Juozas
• Koncevičius, Karolis
• Petronis, Art

Titel

Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging

Ist Teil von

• Nature communications, 2018-02, Vol.9 (1), p.644-11, Article 644

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism's deterioration.