International journal of molecular sciences, 2020-04, Vol.21 (9), p.3165
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Type 3 Diabetes and Its Role Implications in Alzheimer's Disease
- Ist Teil von
- International journal of molecular sciences, 2020-04, Vol.21 (9), p.3165
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in debate. However, poorly controlled blood sugar may increase the risk of developing Alzheimer's. This relationship is so strong that some have called Alzheimer's "diabetes of the brain" or "type 3 diabetes (T3D)". Given more recent studies continue to indicate evidence linking T3D with AD, this review aims to demonstrate the relationship between T3D and AD based on the fact that both the processing of amyloid-β (Aβ) precursor protein toxicity and the clearance of Aβ are attributed to impaired insulin signaling, and that insulin resistance mediates the dysregulation of bioenergetics and progress to AD. Furthermore, insulin-related therapeutic strategies are suggested to succeed in the development of therapies for AD by slowing down their progressive nature or even halting their future complications.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms21093165Titel-ID: cdi_doaj_primary_oai_doaj_org_article_8977af7a9b684d508d5510b893e4cb44
- Format
- –
- Schlagworte
- Alzheimer Disease - etiology, Alzheimer Disease - metabolism, Alzheimer's disease, Amyloid beta-Peptides - metabolism, Amyloid beta-Protein Precursor - metabolism, Amyloid precursor protein, Animals, Bioenergetics, Blood Glucose, Brain - metabolism, Brain - pathology, Dementia, Diabetes, Diabetes Complications - metabolism, Diabetes mellitus (non-insulin dependent), Diabetes Mellitus - metabolism, Disease Susceptibility, Glucagon - metabolism, Glucose, Glucose - metabolism, Humans, hypometabolism, Insulin, Insulin - metabolism, Insulin Resistance, Insulin-like growth factors, Memory, Mortality, Neurodegeneration, Review, RNA polymerase, Signal Transduction, Toxicity, type 2 diabetes, type 3 diabetes