Details

Autor(en) / Beteiligte

• Farahat, Ramadan Abdelmoez
• Nazir, Abubakar
• Ochani, Sidhant
• Khan, Sheharyar Hassan
• Mahjabin, Annama
• Mohammed, Saleh
• Jahan, Israt
• Kubra, Khadizatul
• Swed, Sarya
• Dhama, Kuldeep

Titel

Hidden relationship between sarcoidosis and gut microbiota: recent evidence and future implications

Ist Teil von

• The Egyptian journal of internal medicine, 2023-02, Vol.35 (1), p.17-4, Article 17

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Transforming growth factor β (TGF-β), Toll-like receptor 4 (TLR-4), and tumor necrosis factor α (TNF-α) increase the susceptibility to sarcoidosis [4]. Patients having hepatitis C virus infection, when treated with interferon α therapy, may develop sarcoidosis [5]. Apart from the direct role of pathogens in the pathogenesis of sarcoidosis, several other factors have been seen to have an association with gut microbiota and diseases, which include genetic factors as the bacteria synthesize different metabolites based on different genetic makeup, maintaining a stable environment, and sex differences as the microbiota have been seen to have a role in regulating sex hormones that can affect a particular sex-based severity of auto-immune diseases [5]. [...]future research is needed to identify, and search for principal sources, inflammatory processes caused by gut microbiota, new therapeutic targets, and biomarkers, and to understand the positive and negative effects of these gut microbes on human health amidst a considerable increase in autoimmune and inflammatory disease worldwide.