Details

Autor(en) / Beteiligte

• Mufti, Ghulam J
• Bennett, John M
• Goasguen, Jean
• Bain, Barbara J
• Baumann, Irith
• Brunning, Richard
• Cazzola, Mario
• Fenaux, Pierre
• Germing, Ulrich
• Hellstrom-Lindberg, Eva
• Jinnai, Itsuro
• Manabe, Atsushi
• Matsuda, Akira
• Niemeyer, Charlotte M
• Sanz, Guillermo
• Tomonaga, Masao
• Vallespi, Teresa
• Yoshimi, Ayami

Titel

Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts

Ist Teil von

• Haematologica, 2008-11, Vol.93 (11), p.1712-1717

Ort / Verlag

Pavia: Haematologica

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• 1 King’s College, London, United Kingdom 2 James P. Wilmot Cancer Center, Rochester, New York, USA 3 Université de Rennes, Rennes, France 4 St. Mary’s Hospital Campus of Imperial College, London, United Kingdom 5 Institute of Pathology, Medical Hospital, Bayreuth, Germany 6 University of Minnesota, Minneapolis, Minnesota, USA 7 University of Pavia and Fondazione IRCCS Policlinico San Matteo, Italy 8 Université Paris XIII, Bobigny, France 9 University Dusseldorf, Dusseldorf, Germany 10 Karolinska Institute, Stockholm, Sweden 11 Saitama Medical University, Saitama, Japan 12 St Luke’s International Hospital, Chuo-ku, Japan 13 Saitama Medical University, Saitama, Japan 14 University of Freiburg, Freiburg, Germany 15 Hospital Universitario La Fe, Valencia, Spain 16 Nagasaki University School of Medicine, Nagasaki, Japan 17 Hospital Universitario Vall d’Hebron, Barcelona, Spain and 18 University of Freiburg, Freiburg, Germany Correspondence: Ghulam Mufti, Department of Haematology, King’s College Hospital, Denmark Hill, London, SE5 9RS United Kingdom. E.mail: ghulam.mufti{at}kcl.ac.uk ABSTRACT The classification of myelodysplastic syndromes is based on the morphological criteria proposed by the French-American-British (FAB) and World Health Organization (WHO) groups. Accurate enumeration of blast cells, although essential for diagnosis of myelodysplastic syndrome and for assignment to prognostic groups, is often difficult, due to imprecise criteria for the morphological definition of blasts and promyelocytes. An International Working Group on Morphology of Myelodysplastic Syndrome (IWGM-MDS) of hematopathologists and hematologists expert in the field of myelodysplastic syndrome reviewed the morphological features of bone marrows from all subtypes of myelodysplastic syndrome and agreed on a set of recommendations, including recommendations for the definition and enumeration of blast cells and ring sideroblasts. It is recommended that (1) agranular or granular blast cells be defined (replacing the previous type I, II and III blasts), (2) dysplastic promyelocytes be distinguished from cytologically normal promyelocytes and from granular blast cells, (3) sufficient cells be counted to give a precise blast percentage, particularly at thresholds that are important for diagnosis or prognosis and (4) ring sideroblasts be defined as erythroblasts in which there are a minimum of 5 siderotic granules covering at least a third of the nuclear circumference. Clear definitions and a differential count of a sufficient number of cells is likely to improve precision in the diagnosis and classification of myelodysplastic syndrome. Recommendations should be applied in the context of the WHO classification. Key words: myelodysplastic syndrome, myelodysplastic syndrome, myeloblast, ring sideroblast.