Details

Autor(en) / Beteiligte

• Singh, Vidisha
• Obregon-Perko, Veronica
• Lapp, Stacey A
• Horner, Anna Marie
• Brooks, Alyssa
• Macoy, Lisa
• Hussaini, Laila
• Lu, Austin
• Gibson, Theda
• Silvestri, Guido
• Grifoni, Alba
• Weiskopf, Daniela
• Sette, Alessandro
• Anderson, Evan J
• Rostad, Christina A
• Chahroudi, Ann

Titel

Limited induction of SARS-CoV-2-specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19

Ist Teil von

• JCI insight, 2022-02, Vol.7 (4)

Ort / Verlag

United States: American Society for Clinical Investigation

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Why multisystem inflammatory syndrome in children (MIS-C) develops after SARS-CoV-2 infection in a subset of children is unknown. We hypothesized that aberrant virus-specific T cell responses contribute to MIS-C pathogenesis. We quantified SARS-CoV-2-reactive T cells, serologic responses against major viral proteins, and cytokine responses from plasma and peripheral blood mononuclear cells in children with convalescent COVID-19, in children with acute MIS-C, and in healthy controls. Children with MIS-C had significantly lower virus-specific CD4+ and CD8+ T cell responses to major SARS-CoV-2 antigens compared with children convalescing from COVID-19. Furthermore, T cell responses in participants with MIS-C were similar to or lower than those in healthy controls. Serologic responses against spike receptor binding domain (RBD), full-length spike, and nucleocapsid were similar among convalescent COVID-19 and MIS-C, suggesting functional B cell responses. Cytokine profiling demonstrated predominant Th1 polarization of CD4+ T cells from children with convalescent COVID-19 and MIS-C, although cytokine production was reduced in MIS-C. Our findings support a role for constrained induction of anti-SARS-CoV-2-specific T cells in the pathogenesis of MIS-C.