International journal of molecular sciences, 2020-08, Vol.21 (16), p.5624
2020
Details
- Autor(en) / Beteiligte
- Titel
- Involvement of p38 MAPK in Synaptic Function and Dysfunction
- Ist Teil von
- International journal of molecular sciences, 2020-08, Vol.21 (16), p.5624
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) and long-term depression (LTD). However, p38 MAPK is classically known as a responsive element to stress stimuli, including neuroinflammation. Specific to the pathophysiology of Alzheimer's disease (AD), several studies have shown that the p38 MAPK cascade is activated either in response to the Aβ peptide or in the presence of tauopathies. Here, we describe the role of p38 MAPK in the regulation of synaptic plasticity and its implication in an animal model of neurodegeneration. In particular, recent evidence suggests the p38 MAPK α isoform as a potential neurotherapeutic target, and specific inhibitors have been developed and have proven to be effective in ameliorating synaptic and memory deficits in AD mouse models.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms21165624Titel-ID: cdi_doaj_primary_oai_doaj_org_article_858ec8d2f76048ab9ce13d4539d1fde0
- Format
- –
- Schlagworte
- Alzheimer's disease, Animal models, Animals, Brain, Brain - pathology, Cytokines, Enzymes, Humans, Inflammation, Inflammation - pathology, Kinases, Long-term depression, Long-term potentiation, MAP kinase, Neural plasticity, Neurodegeneration, neuroinflammation, Neurons, p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors, p38 Mitogen-Activated Protein Kinases - metabolism, p38-MAPK α inhibitor, Phosphorylation, Protein Kinase Inhibitors - pharmacology, Proteins, Regulatory sequences, Review, Roles, Small Molecule Libraries - pharmacology, Synapses - drug effects, Synapses - enzymology, Synapses - pathology, Synaptic plasticity, Synaptic strength, Tau, Tau protein, Tumor necrosis factor-TNF, β-amyloid