Details

Autor(en) / Beteiligte

• Xu, Qing-Qing
• Li, Qing-Jie
• Chen, Liu
• Su, Xin-Yi
• Song, Jing-Xia
• Du, Juan
• Chen, Lei
• Lu, Li-Xia

Titel

A nomogram for predicting survival of head and neck mucosal melanoma

Ist Teil von

• Cancer cell international, 2021-04, Vol.21 (1), p.224-224, Article 224

Ort / Verlag

England: BioMed Central

Erscheinungsjahr

2021

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• We aimed to understand the clinical characteristics and better predict the prognosis of patients with mucosal melanoma of the head and neck (MMHN) using a nomogram. Three hundred patients with nometastatic MMHN were included. Multivariable Cox regression was performed to analyze independent prognostic factors for overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRRFS), and these factors were used to develop a nomogram. Concordance indexes (C-indexes), calibration plots, and receiver operating characteristic (ROC) analysis were performed to test the predictive performance of the nomogram in both the primary (n = 300) and validation cohorts (n = 182). The primary tumor site, T stage and N stage were independent risk factors for survival and were included in the nomogram to predict the 3- and 5-year OS, DFS, DMFS, and LRRFS in the primary cohort. The C-indexes (both > 0.700), well-fit calibration plots, and area under the ROC curve (both > 0.700) indicated the high diagnostic accuracy of the nomogram, in both the primary and validation cohorts. The patients were divided into three groups (high-risk, intermediate-risk, and low-risk groups) according to their nomogram scores. The survival curves of OS, DFS, DMFS, and LRRFS were well separated by the risk groups in both cohorts (all P < 0.001). The nomogram can stratify MMHN patients into clinically meaningful taxonomies to provide individualized treatment.