International journal of molecular sciences, 2021-09, Vol.22 (18), p.9724
2021
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- Autor(en) / Beteiligte
- Titel
- Sarcopenia: Etiology, Nutritional Approaches, and miRNAs
- Ist Teil von
- International journal of molecular sciences, 2021-09, Vol.22 (18), p.9724
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial syndrome, the etiology and underlying mechanisms are not yet delineated. Moreover, research about nutritional interventions to prevent the development of sarcopenia is mainly focused on the amount and quality of protein intake. The impact of several nutrition strategies that consider timing of food intake, anti-inflammatory nutrients, metabolic control, and the role of mitochondrial function on the progression of sarcopenia is not fully understood. This narrative review summarizes the metabolic background of this phenomenon and proposes an integral nutritional approach (including dietary supplements such as creatine monohydrate) to target potential molecular pathways that may affect reduce or ameliorate the adverse effects of sarcopenia. Lastly, miRNAs, in particular those produced by skeletal muscle (MyomiR), might represent a valid tool to evaluate sarcopenia progression as a potential rapid and early biomarker for diagnosis and characterization.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms22189724Titel-ID: cdi_doaj_primary_oai_doaj_org_article_83fdcf82c22943a68f147b01fc4f0413
- Format
- –
- Schlagworte
- Aging, Aging - physiology, Autophagy, Biomarkers, Chronic illnesses, Creatine, Diabetes, Dietary Supplements, Disease Management, Disease Susceptibility, Estrogens, Etiology, Exercise, Food intake, Hormones, Humans, Inflammation, Insulin-like growth factors, Kinases, Life expectancy, Lifestyles, Metabolism, MicroRNAs - genetics, Mitochondria, Mitochondria - metabolism, muscle, Muscle strength, Muscle, Skeletal - metabolism, Muscle, Skeletal - pathology, Muscles, Musculoskeletal system, MyomiR, Nutrients, Nutrition, nutritional supplements, Older people, Oxidative Stress, Physical fitness, protein, Protein synthesis, Proteins, Quality of life, Review, Sarcopenia, Sarcopenia - diagnosis, Sarcopenia - etiology, Sarcopenia - therapy, Skeletal muscle, Womens health, Working groups