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Causal effects of gut microbiome on hypertension: a Mendelian randomization study
Ist Teil von
Frontiers in microbiology, 2023-11, Vol.14, p.1276050-1276050
Ort / Verlag
Switzerland: Frontiers Media S.A
Erscheinungsjahr
2023
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Previous observational studies have shown that there is an important relationship between gut microbiota and hypertension, we performed a two-sample Mendelian randomization analysis to examine whether the gut microbiota is causally related to hypertension in order to find a basis for potential diagnostic or intervention approaches for hypertension.
We obtained significant single nucleotide polymorphisms related to gut microbiota and hypertension from publicly available genome-wide association studies for a two-sample Mendelian randomization study. A total of 18,340 individual genome-wide genotype data were included from 24 population-based cohorts. The inverse-variance weighted meta-analysis is the main analytical method for evaluating causal relationships, and the Mendelian randomization research results have been validated through a series of sensitivity analyses.
The inverse-variance weighted analysis results indicated that phylum
(OR:0.831, 95%CI: 0.710-0.972;
= 0.021), family
(OR:0.672, 95%CI: 0.496-0.911;
= 0.01), family
(OR:0.709, 95%CI:0.569-0.884,
= 0.002), genus
(OR: 0.991, 95%CI: 0.982-0.999,
= 0.035), genus
(OR:0.819, 95%CI:0.685-0.981;
= 0.03), genus
(OR:0.990, 95%CI:0.981-0.999;
= 0.025), and genus
(OR:0.988, 95%CI: 0.979-0.997;
= 0.008) had protective causal effects on hypertension. The Family
(OR:1.011, 95%CI:1.000-1.021,
= 0.04), Genus
(OR:1.375, 95%CI:1.096-1.653;
= 0.025), Genus
(OR:1.899, 95%CI:1.361-2.348;
= 0.02), and Genus
(OR:1.536, 95%CI:1.072-2.202;
= 0.019) were associated with a higher risk of HTN. The reverse Mendelian randomization analysis results showed no reverse causal relationship between HTN and these bacterial taxa.
Our Mendelian randomization analysis results indicate a potential causal relationship between these bacterial taxa and hypertension, providing a new perspective for the treatment and prevention of hypertension.