Details

Autor(en) / Beteiligte

• Vázquez-Oliver, Anna
• Brambilla-Pisoni, Cecilia
• Domingo-Gainza, Mikel
• Maldonado, Rafael
• Ivorra, Antoni
• Ozaita, Andrés

Titel

Auricular transcutaneous vagus nerve stimulation improves memory persistence in naïve mice and in an intellectual disability mouse model

Ist Teil von

• Brain stimulation, 2020-03, Vol.13 (2), p.494-498

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Vagus nerve stimulation (VNS) using non-invasive approaches have attracted great attention due to their anti-epileptic, anti-depressive and pro-cognitive effects. It has been proposed that auricular transcutaneous VNS (atVNS) could benefit intellectual disability disorders, but preclinical data supporting this idea is limited. To develop an atVNS device for mice and to test its efficacy on memory performance in naïve mice and in a mouse model for intellectual disability. Naïve outbreed CD-1 mice and a model for fragile X syndrome, the Fmr1 knockout (Fmr1KO), were used to assess the effect of atVNS in the novel object-recognition memory performance. We found that atVNS significantly improves memory persistence in naïve mice. Notably, atVNS was efficacious in normalizing the object-recognition memory deficit in the Fmr1KO model. Our data show that atVNS improves memory persistence in naïve mice and in a model of intellectual disability and support further studies taking advantage of preclinical mouse models of cognitive disorders. •Auricular transcutaneous vagus nerve stimulation was performed in anesthetized mice.•atVNS enhanced non-emotional memory persistence in naïve mice.•atVNS improved memory performance in the Fmr1 KO mouse model for fragile X syndrome.