Details

Autor(en) / Beteiligte

• Puia-Negulescu, Serban
• Lebossé, Fanny
• Mabrut, Jean-Yves
• Muller, Xavier
• Rossignol, Guillaume
• Antonini, Teresa
• Erard, Domitille
• Radenne, Sylvie
• Guillet, Marielle
• Souquet, Jean-Christophe
• Mohkam, Kayvan
• Lesurtel, Mickael

Titel

Liver Transplantation for Colorectal Liver Metastases: Current Management and Future Perspectives

Ist Teil von

• International journal of molecular sciences, 2021-03, Vol.22 (6), p.3093

Ort / Verlag

Switzerland: MDPI

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Patients with nonresectable liver metastases from colorectal cancer have few therapeutic options and a dismal prognosis. Although liver transplantation for this indication has historically a poor reputation, recent advances in the field of chemotherapy and immunosuppression have paved the way to revisit the concept. New data have shown promising results that need to be validated in several ongoing clinical trials. Since liver grafts represent a scarce resource, several new tools are being explored to expand the donor pool for this indication. The purpose of this review is to present all current available data and perspectives about liver transplantation for nonresectable liver metastases from colorectal cancer.