Details

Autor(en) / Beteiligte

• Huang, Qiaoqiao
• Han, Ying
• Shen, Edward
• Feng, Ziyang
• Peng, Yinghui
• Gao, Le
• Gao, Yan
• Liu, Yongting
• Li, Wei
• Liu, Ping
• Chen, Yihong
• Guo, Cao
• Zeng, Shan
• Cai, Changjing
• Shen, Hong

Titel

MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma

Ist Teil von

• iScience, 2023-01, Vol.26 (1), p.105095-105095, Article 105095

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in the world. Mitochondrial fission regulator 2 (MTFR2) is involved in the development of various cancers. However, the roles of MTFR2 in HCC remain unknown. In this study, we conducted a comprehensive analysis of MTFR2 in HCC, which was generated from integrative MTFR2 analyses of eight HCC cell lines, and three datasets (public dataset, real-world dataset, and immunotherapy dataset) derived from bulk HCC tissues, survival, and immunotherapy data. We demonstrated that the expression level of MTFR2 is upregulated in HCC, leading to poor prognosis. MTFR2 is positively correlated with the level of immune cell infiltration, multiple immune checkpoints and immunotherapy response prediction pathways, and acts as an important role in cancer-immunity cycle. In conclusion, our work indicates that MTFR2 can shape a barrier of immune microenvironment and result in poor prognosis in hepatocellular carcinoma, but the immune barrier may be broken by immunotherapy. [Display omitted] •MTFR2 is upregulated in HCC, leading to shorter OS and worse DFS in patients•MTFR2 is positively related with immune cell infiltration level and immune checkpoints•MTFR2 may act as an important role in cancer-immunity cycle•MTFR2 can shape a barrier of immune microenvironment, but may be broken by immunotherapy Biological sciences; Cancer; Immunology