Details

Autor(en) / Beteiligte

• Larsen, Jannik B
• Rosholm, Kadla R
• Kennard, Celeste
• Pedersen, Søren L
• Munch, Henrik K
• Tkach, Vadym
• Sakon, John J
• Bjørnholm, Thomas
• Weninger, Keith R
• Bendix, Poul Martin
• Jensen, Knud J
• Hatzakis, Nikos S
• Uline, Mark J
• Stamou, Dimitrios

Titel

How Membrane Geometry Regulates Protein Sorting Independently of Mean Curvature

Ist Teil von

• ACS central science, 2020-07, Vol.6 (7), p.1159-1168

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Freely accessible e-journals

Beschreibungen/Notizen

• Biological membranes have distinct geometries that confer specific functions. However, the molecular mechanisms underlying the phenomenological geometry/function correlations remain elusive. We studied the effect of membrane geometry on the localization of membrane-bound proteins. Quantitative comparative experiments between the two most abundant cellular membrane geometries, spherical and cylindrical, revealed that geometry regulates the spatial segregation of proteins. The measured geometry-driven segregation reached 50-fold for membranes of the same mean curvature, demonstrating a crucial and hitherto unaccounted contribution by Gaussian curvature. Molecular-field theory calculations elucidated the underlying physical and molecular mechanisms. Our results reveal that distinct membrane geometries have specific physicochemical properties and thus establish a ubiquitous mechanistic foundation for unravelling the conserved correlations between biological function and membrane polymorphism.