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Impact of cytogenetic abnormalities in symptomatic multiple myeloma; a Japanese real-world analysis from Kansai Myeloma Forum
Ist Teil von
Leukemia research reports, 2023-01, Vol.20, p.100395-100395, Article 100395
Ort / Verlag
England: Elsevier
Erscheinungsjahr
2023
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
To evaluate the specific prognostic value of CAs, we conducted an analysis of 923 symptomatic multiple myeloma patients. Among this cohort, 480 patients had complete data set of high-risk CAs by interphase fluorescent in situ hybridization at diagnosis. In the high-risk group analysis, the median OS of patients without CAs (
= 338, 72 %) was 6.5 years, patients with del(17p) (
= 42, 9 %) was 4.4 years, patients with t(4;14) or t(14;16) (
= 72, 15 %) was 4.4 years, and patients with double-positive CAs(del(17p) and t(4;14) or t(14;16)) (
= 18, 4 %) was 2.1 years (
= 0.032). Patients with double-positive CAs had a significantly worse prognosis.