Details

Autor(en) / Beteiligte

• Lasocki, Arian
• Abdalla, Gehad
• Chow, Geoffrey
• Thust, Stefanie C

Titel

Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review

Ist Teil von

• Cancer imaging, 2022-11, Vol.22 (1), p.1-63, Article 63

Ort / Verlag

London: BioMed Central Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

SpringerLink Journals

Beschreibungen/Notizen

• Background Advances in molecular diagnostics accomplished the discovery of two malignant glioma entities harboring alterations in the H3 histone: diffuse midline glioma, H3 K27-altered and diffuse hemispheric glioma, H3 G34-mutant. Radiogenomics research, which aims to correlate tumor imaging features with genotypes, has not comprehensively examined histone-altered gliomas (HAG). The aim of this research was to synthesize the current published data on imaging features associated with HAG. Methods A systematic search was performed in March 2022 using PubMed and the Cochrane Library, identifying studies on the imaging features associated with H3 K27-altered and/or H3 G34-mutant gliomas. Results Forty-seven studies fulfilled the inclusion criteria, the majority on H3 K27-altered gliomas. Just under half (21/47) were case reports or short series, the remainder being diagnostic accuracy studies. Despite heterogeneous methodology, some themes emerged. In particular, enhancement of H3 K27M-altered gliomas is variable and can be less than expected given their highly malignant behavior. Low apparent diffusion coefficient values have been suggested as a biomarker of H3 K27-alteration, but high values do not exclude this genotype. Promising correlations between high relative cerebral blood volume values and H3 K27-alteration require further validation. Limited data on H3 G34-mutant gliomas suggest some morphologic overlap with 1p/19q-codeleted oligodendrogliomas. Conclusions The existing data are limited, especially for H3 G34-mutant gliomas and artificial intelligence techniques. Current evidence indicates that imaging-based predictions of HAG are insufficient to replace histological assessment. In particular, H3 K27-altered gliomas should be considered when occurring in typical midline locations irrespective of enhancement characteristics. Keywords: Magnetic resonance imaging, Radiogenomics, H3 K27M-altered glioma, H3 G34-mutant glioma