Details

Autor(en) / Beteiligte

• Benkert, Julia
• Hess, Simon
• Roy, Shoumik
• Beccano-Kelly, Dayne
• Wiederspohn, Nicole
• Duda, Johanna
• Simons, Carsten
• Patil, Komal
• Gaifullina, Aisylu
• Mannal, Nadja
• Dragicevic, Elena
• Spaich, Desirée
• Müller, Sonja
• Nemeth, Julia
• Hollmann, Helene
• Deuter, Nora
• Mousba, Yassine
• Kubisch, Christian
• Poetschke, Christina
• Striessnig, Joerg
• Pongs, Olaf
• Schneider, Toni
• Wade-Martins, Richard
• Patel, Sandip
• Parlato, Rosanna
• Frank, Tobias
• Kloppenburg, Peter
• Liss, Birgit

Titel

Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease

Ist Teil von

• Nature communications, 2019-11, Vol.10 (1), p.5094-11, Article 5094

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Degeneration of dopaminergic neurons in the substantia nigra causes the motor symptoms of Parkinson's disease. The mechanisms underlying this age-dependent and region-selective neurodegeneration remain unclear. Here we identify Cav2.3 channels as regulators of nigral neuronal viability. Cav2.3 transcripts were more abundant than other voltage-gated Ca channels in mouse nigral neurons and upregulated during aging. Plasmalemmal Cav2.3 protein was higher than in dopaminergic neurons of the ventral tegmental area, which do not degenerate in Parkinson's disease. Cav2.3 knockout reduced activity-associated nigral somatic Ca signals and Ca -dependent after-hyperpolarizations, and afforded full protection from degeneration in vivo in a neurotoxin Parkinson's mouse model. Cav2.3 deficiency upregulated transcripts for NCS-1, a Ca -binding protein implicated in neuroprotection. Conversely, NCS-1 knockout exacerbated nigral neurodegeneration and downregulated Cav2.3. Moreover, NCS-1 levels were reduced in a human iPSC-model of familial Parkinson's. Thus, Cav2.3 and NCS-1 may constitute potential therapeutic targets for combatting Ca -dependent neurodegeneration in Parkinson's disease.