Details

Autor(en) / Beteiligte

• Dwyer, Connor J.
• Cloud, Colleen A.
• Wang, Cindy
• Heidt, Philip
• Chakraborty, Paramita
• Duke, Tara F.
• McGue, Shannon
• Jeffcoat, Braxton
• Dunne, Jaclyn
• Johnson, Logan
• Choi, Seungho
• Nahhas, Georges J.
• Gandy, Amy S.
• Babic, Nikolina
• Nolte, Frederick S.
• Howe, Philip
• Ogretmen, Besim
• Gangaraju, Vamsi K.
• Tomlinson, Stephen
• Madden, Brian
• Bridges, Tracy
• Flume, Patrick A.
• Wrangle, John
• Rubinstein, Mark P.
• Baliga, Prabhakar K.
• Nadig, Satish N.
• Mehrotra, Shikhar

Titel

Comparative analysis of antibodies to SARS-CoV-2 between asymptomatic and convalescent patients

Ist Teil von

• iScience, 2021-06, Vol.24 (6), p.102489-102489, Article 102489

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The SARS-CoV-2 viral pandemic has induced a global health crisis, which requires more in-depth investigation into immunological responses to develop effective treatments and vaccines. To understand protective immunity against COVID-19, we screened over 60,000 asymptomatic individuals in the Southeastern United States for IgG antibody positivity against the viral Spike protein, and approximately 3% were positive. Of these 3%, individuals with the highest anti-S or anti-RBD IgG level showed a strong correlation with inhibition of ACE2 binding and cross-reactivity against non-SARS-CoV-2 coronavirus S-proteins. We also analyzed samples from 94 SARS-CoV-2 patients and compared them with those of asymptomatic individuals. SARS-CoV-2 symptomatic patients had decreased antibody responses, ACE2 binding inhibition, and antibody cross-reactivity. Our study shows that healthy individuals can mount robust immune responses against SARS-CoV-2 without symptoms. Furthermore, IgG antibody responses against S and RBD may correlate with high inhibition of ACE2 binding in individuals tested for SARS-CoV-2 infection or post vaccination. [Display omitted] •60,000 asymptomatic individuals were assessed for SARS-CoV-2 antibody responses•Increased Spike IgG correlates with antibody diversity and ACE2 binding inhibition•COVID-19 patients had lower antibody responses compared with high asymptomatic responders•Individuals can mount diverse immune responses to COVID-19 without symptoms Infection control in health technology; Immunology; Virology