Details

Autor(en) / Beteiligte

• Wollsching-Strobel, Maximilian
• Schwarz, Sarah Bettina
• Mathes, Tim
• Majorski, Daniel Sebastian
• Heidari, Pouya
• Kroppen, Doreen
• Magnet, Friederike Sophie
• Windisch, Wolfram

Titel

Anemia Severely Reduces Health-Related Quality of Life in COPD Patients Receiving Long-Term Home Non-Invasive Ventilation

Ist Teil von

• International journal of chronic obstructive pulmonary disease, 2021-01, Vol.16, p.2963-2971

Ort / Verlag

New Zealand: Dove Medical Press Limited

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• To assess the influence of anemia on health-related quality of life (HRQL) in COPD patients receiving long-term non-invasive ventilation (NIV). In this prospective single-center cohort study, COPD patients on long-term NIV were analyzed between June 2015 and May 2020. Linear multiple regression analyses were performed using the results of the Severe Respiratory Insufficiency Questionnaire (SRI) along with the following variables: sex, age, body mass index, duration of NIV, exacerbation history (≤1 versus >1 in the previous year), the updated Charlson comorbidity index, hemoglobin levels and anemia (WHO criteria). Anemia was identified in 32.8% (N=128). Anemia (mean difference -8.4, 95% CI -2.0/-14.9 SRI points, =0.011) and exacerbations (mean difference -9.9, 95% CI -4.3/-15.5 SRI points, =0.001) each had a negative impact on SRI summary scores. Exacerbations were negatively associated with six out of seven SRI subscale scores, while anemia was negatively associated with four out of seven. SRI summary scores dropped by 1.5 points for every g/dl of hemoglobin ( =0.08). No other variables had an influence on the SRI scores. The present study has shown that within a cohort of COPD patients undergoing long-term NIV, one-third were identified as anemic. Furthermore, anemia, like exacerbation history, was found to have a considerable negative impact on HRQL that is specific to patients with chronic respiratory failure. German Clinical Trials Registry (DRKS00008759).