Details

Autor(en) / Beteiligte

• Kondkar, Altaf A
• Azad, Taif A
• Sultan, Tahira
• Khatlani, Tanvir
• Alshehri, Abdulaziz A
• Radhakrishnan, Rakesh
• Lobo, Glenn P
• Alsirhy, Ehab
• Almobarak, Faisal A
• Osman, Essam A
• Al-Obeidan, Saleh A

Titel

APOE ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin

Ist Teil von

• International journal of molecular sciences, 2024-04, Vol.25 (8), p.4571

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• This study investigated the association between apolipoprotein E ( ) gene polymorphisms (rs429358 and rs7412) and primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG) in a Saudi cohort. Genotyping of 437 DNA samples (251 controls, 92 PACG, 94 PXG) was conducted using PCR-based Sanger sequencing. The results showed no significant differences in the allele and genotype frequencies of rs429358 and rs7412 between the PACG/PXG cases and controls. Haplotype analysis revealed ε3 as predominant, followed by ε4 and ε2 alleles, with no significant variance in PACG/PXG. However, genotype analysis indicated a significant association between ε2-carriers and PACG (odds ratio = 4.82, 95% CI 1.52-15.26, = 0.007), whereas no notable association was observed with PXG. Logistic regression confirmed ε2-carriers as a significant predictor for PACG ( = 0.008), while age emerged as significant for PXG ( < 0.001). These findings suggest a potential role of ε2-carriers in PACG risk within the Saudi cohort. Further validation and larger-scale investigations are essential to elucidate the precise role of in PACG pathogenesis and progression.