Details

Autor(en) / Beteiligte

• Hassan, Ahmed O.
• Feldmann, Friederike
• Zhao, Haiyan
• Curiel, David T.
• Okumura, Atsushi
• Tang-Huau, Tsing-Lee
• Case, James Brett
• Meade-White, Kimberly
• Callison, Julie
• Chen, Rita E.
• Lovaglio, Jamie
• Hanley, Patrick W.
• Scott, Dana P.
• Fremont, Daved H.
• Feldmann, Heinz
• Diamond, Michael S.

Titel

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

Ist Teil von

• Cell reports. Medicine, 2021-04, Vol.2 (4), p.100230, Article 100230

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The deployment of a vaccine that limits transmission and disease likely will be required to end the coronavirus disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally administered chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabilized spike (S) protein (ChAd-SARS-CoV-2-S [chimpanzee adenovirus-severe acute respiratory syndrome-coronavirus-2-S]) in the upper and lower respiratory tracts of mice expressing the human angiotensin-converting enzyme 2 (ACE2) receptor. Here, we show the immunogenicity and protective efficacy of this vaccine in non-human primates. Rhesus macaques were immunized with ChAd-Control or ChAd-SARS-CoV-2-S and challenged 1 month later by combined intranasal and intrabronchial routes with SARS-CoV-2. A single intranasal dose of ChAd-SARS-CoV-2-S induces neutralizing antibodies and T cell responses and limits or prevents infection in the upper and lower respiratory tracts after SARS-CoV-2 challenge. As ChAd-SARS-CoV-2-S confers protection in non-human primates, it is a promising candidate for limiting SARS-CoV-2 infection and transmission in humans. [Display omitted] ChAd-SARS-CoV-2 is a chimpanzee adenoviral vectored vaccine against SARS-CoV-2ChAD-SARS-CoV-2-S immunization induces neutralizing Abs and T cell responses in NHPChAD-SARS-CoV-2-S protects NHPs against infection in the respiratory tractVaccine-induced serum neutralizing antibody titers correlate with the protection Hassan et al. show that a single-dose immunization of rhesus monkeys with ChAd-SARS-CoV-2-S via an intranasal route induces neutralizing antibodies and T cell responses against SARS-CoV-2. ChAd-SARS-CoV-2-S vaccine protects rhesus monkeys against SARS-CoV-2 infection in both the upper and lower respiratory tracts.