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Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children
Ist Teil von
Genes, 2020-09, Vol.11 (9), p.1099
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2020
Quelle
MEDLINE
Beschreibungen/Notizen
Bacterial meningitis (BM) is a severe disease caused by various bacterial pathogens. Toll-like receptors (TLRs) protect humans from invading pathogens. In this study, we determined whether single nucleotide polymorphisms (SNPs) of
and
are associated with susceptibility to and outcome of BM in Angolan children. Samples were taken from 241 patients and 265 age-matched ethnic controls. The SNPs
rs4986790 (896A > G) and
rs187084 (-1486T > C) were determined by high-resolution melting analysis (HRMA). The frequency of variant genotypes in
was significantly higher in patients with
meningitis than controls (odds ratio (OR), 2.5; 95% confidence interval (CI), 1.2-5.4;
= 0.021), whereas the frequency of variant genotypes in
was significantly lower in patients with
meningitis than controls (OR, 0.4; 95% CI, 0.2-0.9;
= 0.036). No such differences were found with other causative pathogens, such as
and
. At the time of discharge, patients with meningitis caused by Gram-negative bacteria who were carriers of variant
genotypes had a higher risk of ataxia (OR, 12.91; 95% CI, 1.52-109.80;
= 0.019) and other neurological sequelae (OR, 11.85; 95% CI, 1.07-131.49;
= 0.044) than those with the wild-type
genotype. Our study suggests an association between
meningitis and genetic variation between
and
in Angolan children.