Details

Autor(en) / Beteiligte

• Yang, Yan
• Lin, Zeyang
• Han, Zhaopu
• Wu, Zhengxin
• Hua, Jianyu
• Zhong, Rui
• Zhao, Ruidan
• Ran, Honggang
• Qu, Kaiyong
• Huang, Hongfei
• Tang, Huamei
• Huang, Jiyi
• Liu, Zhongchen
• Hong, Xuehui
• Peng, Zhihai
• Zhuang, Guohong

Titel

miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE

Ist Teil von

• Cell death discovery, 2021-10, Vol.7 (1), p.272-272, Article 272

Ort / Verlag

New York: Springer Nature B.V

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Abstract Colorectal cancer (CRC) is a common tumor that harms human health with a high recurrence rate. It has been reported that the expression of microRNA-539 (miR-539) is low in several types of cancer, including CRC. Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8/TIPE) is highly expressed in CRC and promotes the proliferation, migration and angiogenesis of CRC. However, the relationship between miR-539 and TIPE and the mechanisms by which they regulate the proliferation of CRC remain to be explored. We aimed to investigate the functions and mechanisms of miR-539 in CRC proliferation. Functionally, miR-539 can bind to and regulate the expression of TIPE, and miR-539 activates SAPK/JNK to downregulate the expression of glutathione peroxidase 4 (GPX4) and promote ferroptosis. Our data reveal the novel role of miR-539 in regulating ferroptosis in CRC via activation of the SAPK/JNK axis, providing new insight into the mechanism of abnormal proliferation in CRC and a novel potential therapeutic target for advanced CRC.