Details

Autor(en) / Beteiligte

• Hazrati, Ali
• Mirsanei, Zahra
• Heidari, Neda
• Malekpour, Kosar
• Rahmani-Kukia, Nasim
• Abbasi, Ardeshir
• Soudi, Sara

Titel

The potential application of encapsulated exosomes: A new approach to increase exosomes therapeutic efficacy

Ist Teil von

• Biomedicine & pharmacotherapy, 2023-06, Vol.162, p.114615-114615, Article 114615

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Cell therapy is one of the methods that have shown promising results in treating diseases in recent decades. However, the use of different types of cells comes with limitations. The application of immune cells in cell therapy can lead to cytokine storms and inappropriate responses to self-antigens. Also, the use of stem cells has the potential to create tumors. Also, cells may not migrate to the injury site after intravenous injection. Therefore, using exosomes from different cells as therapeutic candidates were proposed. Due to their small size and favorable characteristics, such as biocompatibility and immunocompatibility, the easy storage and isolation, exosomes have attracted much attention. They are used in treating many diseases, including cardiovascular diseases, orthopedic diseases, autoimmune diseases, and cancer. However, the results of various studies have shown that the therapeutic efficiency of exosomes (Exo) can be increased by loading different drugs and microRNAs inside them (encapsulated exosomes). Therefore, analyzing studies investigating encapsulated exosomes' therapeutic ability is critical. In this study, we have examined the studies related to the use of encapsulated exosomes in treating diseases such as cancer and infectious diseases and their use in regenerative medicine. Compared to intact exosomes, the results show that the application of encapsulated exosomes has a higher therapeutic ability. Therefore it is suggested to use this method depending on the treatment type to increase the treatment's efficiency. [Display omitted] •The use of encapsulated exosomes has a higher therapeutic efficiency than intact exosomes.•Different drugs with the purpose of treating various diseases have the possibility of being loaded in exosomes.•The load of chemotherapy drugs can lead to an increase in the apoptosis of tumor cells.•Exosomes encapsulated with microbial antigens can be used as new-generation vaccines.