Details

Autor(en) / Beteiligte

• Belachew, Esmael Besufikad
• Desta, Adey Feleke
• Deneke, Dinikisira Bekele
• Gebremariam, Tewodros Yalew
• Tefera, Dessalegn Abeje
• Atire, Fikadu Alemu
• Alemayehu, Dawit Hailu
• Seyoum, Tamirayehu
• Bauer, Marcus
• Girma, Selfu
• Sewasew, Dareskedar Tsehay
• Kantelhardt, Eva J
• Tessema, Tesfaye Sisay
• Howe, Rawleigh

Titel

The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients

Ist Teil von

• BMC research notes, 2023-10, Vol.16 (1), p.1-253, Article 253

Ort / Verlag

London: BioMed Central Ltd

Erscheinungsjahr

2023

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Matrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an association between MMP-2, MMP-9, and MMP-11 expression and clinicopathological characteristics of breast cancer (BC); however, no research has been done on the MMP expression levels in BC cases from Ethiopia. A total of 58 formalin-fixed paraffin-embedded breast tissue samples encompassing 16 benign breast tumors and 42 BC were collected. The RNA was extracted and quantitative reverse-transcription PCR was performed. GraphPad Prism version 8.0.0 was used for statistical analysis. The MMP-11 expression levels were significantly higher in breast cancer cases than in benign breast tumors (P = 0.012). Additionally, BC cases with positive lymph nodes and ER-positive receptors had higher MMP-11, MMP-9, and MMP-2 expression than cases with negative lymph nodes and ER-negative, respectively. The MMP-11 and MMP-9 expressions were higher in grade III and luminal A-like tumors than in grade I-II and other subtypes, respectively. The MMP-11 expression was higher in BC than in benign breast tumors. Additionally, MMP-11, MMP-9, and MMP-2 were higher in BC with positive lymph nodes and estrogen receptors. Our findings suggest an important impact of MMPs in BC pathophysiology, particularly MMP-11.