Nature communications, 2022-01, Vol.13 (1), p.177-177, Article 177
2022
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- Autor(en) / Beteiligte
- Titel
- Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
- Ist Teil von
- Nature communications, 2022-01, Vol.13 (1), p.177-177, Article 177
- Ort / Verlag
- London: Nature Publishing Group UK
- Erscheinungsjahr
- 2022
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model organism, we study the roles of a recently discovered enzyme at the heart of metabolism in mammalian cells, glycerol-3-phosphate phosphatase (G3PP) (gene name Pgp ) that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol. We identify three Pgp homologues in C. elegans ( pgph ) and demonstrate in vivo that their protein products have G3PP activity, essential for glycerol synthesis. We demonstrate that PGPH/G3PP regulates the adaptation to various stresses, in particular hyperosmolarity and glucotoxicity. Enhanced G3PP activity reduces fat accumulation, promotes healthy aging and acts as a calorie restriction mimetic at normal food intake without altering fertility. Thus, PGP/G3PP can be considered as a target for age-related metabolic disorders. Glycerol-3-phosphate phosphatase is a recently discovered enzyme at the heart of metabolism. Here, the authors used C. elegans and showed that its activation promotes stress resistance, healthy aging and acts as a calorie restriction mimetic at normal food intake without altering fertility.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-021-27803-6Titel-ID: cdi_doaj_primary_oai_doaj_org_article_7ec50e33ccdf4e78a7f7c66bddf1bd95
- Format
- –
- Schlagworte
- 631/45/173, 631/45/320, 64, 64/11, Accumulation, Adaptation, Physiological - genetics, Aging, Amino Acid Sequence, Animals, Caenorhabditis elegans - drug effects, Caenorhabditis elegans - genetics, Caenorhabditis elegans - growth & development, Caenorhabditis elegans - metabolism, Caenorhabditis elegans Proteins - genetics, Caenorhabditis elegans Proteins - metabolism, Caloric Restriction, Calories, Eating - genetics, Enzymes, Fertility, Food, Food intake, Gene Expression Regulation, Glucose - metabolism, Glucose - pharmacology, Glycerol, Glycerol - metabolism, Glycerol-3-phosphate, Glycerol-3-Phosphate O-Acyltransferase - genetics, Glycerol-3-Phosphate O-Acyltransferase - metabolism, Glycerophosphates - metabolism, Helminth Proteins - genetics, Helminth Proteins - metabolism, Homology, Humanities and Social Sciences, Isoenzymes - genetics, Isoenzymes - metabolism, Lipids, Longevity - genetics, Mammalian cells, Metabolic disorders, Metabolism, multidisciplinary, Nutrient deficiency, Osmolar Concentration, Osmotic pressure, Phosphatase, Phosphoglycolate phosphatase, Phosphoric Monoester Hydrolases - genetics, Phosphoric Monoester Hydrolases - metabolism, Science, Science (multidisciplinary), Sequence Alignment, Sequence Homology, Amino Acid, Stearoyl-CoA Desaturase - genetics, Stearoyl-CoA Desaturase - metabolism, Stress, Stress, Physiological - genetics, Therapeutic targets, Worms