Molecular medicine (Cambridge, Mass.), 2020-10, Vol.26 (1), p.97-97, Article 97
2020
Details
- Autor(en) / Beteiligte
- Titel
- IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19
- Ist Teil von
- Molecular medicine (Cambridge, Mass.), 2020-10, Vol.26 (1), p.97-97, Article 97
- Ort / Verlag
- England: BioMed Central
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek (Open access)
- Beschreibungen/Notizen
- COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of the activation of many factors involved in it, including inflammation, platelet activation and endothelial dysfunction. Interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1α) are cytokines related to thrombosis. Therefore, this study focused on these three indicators in COVID-19, with the hope to find biomarkers that are associated with patients' outcome. This is a retrospective single-center study involving 74 severe and critically ill COVID-19 patients recruited from the ICU department of the Tongji Hospital in Wuhan, China. The patients were divided into two groups: severe patients and critically ill patients. The serum IP-10, MCP-1 and MIP1α level in both groups was detected using the enzyme-linked immunosorbent assay (ELISA) kit. The clinical symptoms, laboratory test results, and the outcome of COVID-19 patients were retrospectively analyzed. The serum IP-10 and MCP-1 level in critically ill patients was significantly higher than that in severe patients (P < 0.001). However, no statistical difference in MIP1α between the two groups was found. The analysis of dynamic changes showed that these indicators remarkably increased in patients with poor prognosis. Since the selected patients were severe or critically ill, no significant difference was observed between survival and death. IP-10 and MCP-1 are biomarkers associated with the severity of COVID-19 disease and can be related to the risk of death in COVID-19 patients.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1076-1551eISSN: 1528-3658DOI: 10.1186/s10020-020-00230-xTitel-ID: cdi_doaj_primary_oai_doaj_org_article_7ea3562a4c7b4cf2bee002d42f241bc4
- Format
- –
- Schlagworte
- Adaptor Proteins, Signal Transducing - blood, Aged, Betacoronavirus - pathogenicity, Biomarkers, Biomarkers - blood, Blood platelets, Chemokine CCL2 - blood, Chemokine CXCL10 - blood, Chemokines, Coronavirus Infections - complications, Coronavirus Infections - diagnosis, Coronavirus Infections - mortality, Coronavirus Infections - virology, Coronaviruses, Correlation analysis, COVID-19, Critical Illness, Critically ill patients, Cytokine Release Syndrome - complications, Cytokine Release Syndrome - diagnosis, Cytokine Release Syndrome - mortality, Cytokine Release Syndrome - virology, Cytokines, Disease transmission, Disseminated Intravascular Coagulation - complications, Disseminated Intravascular Coagulation - diagnosis, Disseminated Intravascular Coagulation - mortality, Disseminated Intravascular Coagulation - virology, Enzymes, Female, Hospitals, Humans, Hypertension, Infections, IP-10, Male, MCP-1, Medical laboratories, Middle Aged, Pandemics, Patients, Pneumonia, Pneumonia, Viral - complications, Pneumonia, Viral - diagnosis, Pneumonia, Viral - mortality, Pneumonia, Viral - virology, Prognosis, Proteins, Pulmonary Embolism - complications, Pulmonary Embolism - diagnosis, Pulmonary Embolism - mortality, Pulmonary Embolism - virology, Respiratory Insufficiency - complications, Respiratory Insufficiency - diagnosis, Respiratory Insufficiency - mortality, Respiratory Insufficiency - virology, Retrospective Studies, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, Severity of Illness Index, Statistical analysis, Survival Analysis, Thromboembolism, Thrombosis