International journal of molecular sciences, 2020-10, Vol.21 (21), p.8010
2020
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- NAA10 as a New Prognostic Marker for Cancer Progression
- Ist Teil von
- International journal of molecular sciences, 2020-10, Vol.21 (21), p.8010
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- N-α-acetyltransferase 10 (NAA10) is an acetyltransferase that acetylates both N-terminal amino acid and internal lysine residues of proteins. NAA10 is a crucial player to regulate cell proliferation, migration, differentiation, apoptosis, and autophagy. Recently, mounting evidence presented the overexpression of NAA10 in various types of cancer, including liver, bone, lung, breast, colon, and prostate cancers, and demonstrated a correlation of overexpressed NAA10 with vascular invasion and metastasis, thereby affecting overall survival rates of cancer patients and recurrence of diseases. This evidence all points NAA10 toward a promising biomarker for cancer prognosis. Here we summarize the current knowledge regarding the biological functions of NAA10 in cancer progression and provide the potential usage of NAA10 as a prognostic marker for cancer progression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms21218010Titel-ID: cdi_doaj_primary_oai_doaj_org_article_7e645238493e41a9864afddbe5e66f10
- Format
- –
- Schlagworte
- Acetyltransferase, Amino acids, Androgens, Apoptosis, Autophagy, Binding sites, biomarker, Biomarkers, Biomarkers, Tumor - metabolism, Bone cancer, Breast, Cancer, cancer prognosis, Cell cycle, Cell differentiation, Cell proliferation, Colon, Disease Progression, Gene expression, Humans, Kinases, Liver cancer, Localization, Lung cancer, Lysine, Metastases, N-Terminal Acetyltransferase A - metabolism, N-Terminal Acetyltransferase E - metabolism, NAA10, Neoplasms - metabolism, Neoplasms - pathology, Phagocytosis, Phosphorylation, Physiology, Prostate, Prostate cancer, Proteins, Review, Roles, Tumorigenesis