Details

Autor(en) / Beteiligte

• Liu, Runze
• Qin, Song
• Li, Wenjun

Titel

Phycocyanin: Anti-inflammatory effect and mechanism

Ist Teil von

• Biomedicine & pharmacotherapy, 2022-09, Vol.153, p.113362-113362, Article 113362

Ort / Verlag

Elsevier Masson SAS

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• As the host defense response to various injuries and pathogens in the body, inflammation can remove damaged cells and pathogens in the host organism and protect the body. However, excessive inflammation may cause damage to normal tissue cells while removing pathogens, which in turn cause numerous inflammatory diseases and adversely affect the human health. Phycocyanin is an active substance extracted from algae; it has outstanding antioxidant and anti-inflammatory activities, and can effectively inhibit various diseases caused by inflammation. This review systematically summarizes recent applications of phycocyanin against various inflammatory diseases in lung, liver, cardiovascular, and cerebrovascular systems. In addition, possible anti-inflammatory action pathways of phycocyanin are reviewed to canvass the anti-inflammatory mechanism. At last, based on the existing research, phycocyanobilin in phycocyanin is proposed as a bilirubin analog by inducing heme oxygenase 1 in vivo to suppress inflammation. •Many diseases are caused by the body's inflammatory response.•Phycocyanin is a natural active compound derived from seaweed with excellent antioxidant and anti-inflammatory activities.•The application of phycocyanin in inflammatory diseases is summarized.•Proposed possible pathway for phycocyanin to fight inflammation in vivo