Details

Autor(en) / Beteiligte

• Wu, Han
• Chen, Chen
• Gu, Lixing
• Li, Jiapeng
• Yue, Yunqiang
• Lyu, Mengqing
• Cui, Yeting
• Zhang, Xiaoyu
• Liu, Yu
• Zhu, Haichuan
• Liao, Xinghua
• Zhang, Tongcun
• Sun, Fan
• Hu, Weidong

Titel

B cell deficiency promotes the initiation and progression of lung cancer

Ist Teil von

• Frontiers in oncology, 2022-09, Vol.12, p.1006477-1006477

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2022

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Currently commercialized CAR-T cell therapies targeting CD19 and BCMA show great efficacy to cure B cell malignancies. However, intravenous infusion of these CAR-T cells severely destroys both transformed and normal B cells in most tissues and organs, in particular lung, leading to a critical question that what the impact of normal B cell depletion on pulmonary diseases and lung cancer is. Herein, we find that B cell frequency is remarkably reduced in both smoking carcinogen-treated lung tissues and lung tumors, which is associated with advanced cancer progression and worse patient survival. B cell depletion by anti-CD20 antibody significantly accelerates the initiation and progression of lung tumors, which is mediated by repressed tumor infiltration of T cells and macrophage elimination of tumor cells. These findings unveil the overall antitumor activity of B cells in lung cancer, providing novel insights into both mechanisms underlying lung cancer pathogenesis and clinical prevention post CAR-T cell therapy.