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Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study
BMJ open respiratory research, 2023-01, Vol.10 (1), p.e001468
2023

Details

Autor(en) / Beteiligte
Titel
Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study
Ist Teil von
  • BMJ open respiratory research, 2023-01, Vol.10 (1), p.e001468
Ort / Verlag
England: British Thoracic Society
Erscheinungsjahr
2023
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • BackgroundPopulation distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.MethodsA sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determination, 6 min walk test, routine blood analysis and low-dose CT scan with evaluation of lung density and airway wall thickness.ResultsIn never, former and current smokers, prevalence of reduced DLCO was 6.7%, 14.4% and 26.7%, respectively. Current and former smokers with reduced DLCO without airflow limitation were younger than the subjects with normal DLCO, and they had greater levels of dyspnoea and exhaled CO, greater pulmonary artery diameter and lower spirometric parameters, 6 min walk distance, daily physical activity and plasma albumin levels (all p<0.05), with no significant differences in other chronic respiratory symptoms or CT findings. FVC and exhaled CO were identified as independent risk factors for low DLCO.ConclusionReduced DLCO is a frequent disorder among smokers without airflow limitation, associated with decreased exercise capacity and with CT findings suggesting that it may be a marker of smoking-induced early vascular damage.Trial registration numberNCT03028207.
Sprache
Englisch
Identifikatoren
ISSN: 2052-4439
eISSN: 2052-4439
DOI: 10.1136/bmjresp-2022-001468
Titel-ID: cdi_doaj_primary_oai_doaj_org_article_7db4bc74508f446dadb46cd6771eee4b
Format
–
Schlagworte
Carbon Monoxide, Chronic obstructive pulmonary disease, Cigarettes, Dyspnea, Epidemiology, Exercise, Humans, Imaging/CT MRI etc, Lung - diagnostic imaging, Lung diseases, Lung Physiology, Lungs, Medical imaging, Older people, Patients, Physical fitness, Physiology, Population, Population-based studies, Prevalence, Pulmonary arteries, Pulmonary Disease, Chronic Obstructive, Questionnaires, Respiratory Physiology, Smokers, Smoking, Spirometry, Tobacco and the lung, Tomography, Tomography, X-Ray Computed

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