Details

Autor(en) / Beteiligte

• Del Bianco, Diletta
• Gentile, Rosaria
• Sallicandro, Luana
• Biagini, Andrea
• Quellari, Paola Tiziana
• Gliozheni, Elko
• Sabbatini, Paola
• Ragonese, Francesco
• Malvasi, Antonio
• D'Amato, Antonio
• Baldini, Giorgio Maria
• Trojano, Giuseppe
• Tinelli, Andrea
• Fioretti, Bernard

Titel

Electro-Metabolic Coupling of Cumulus-Oocyte Complex

Ist Teil von

• International journal of molecular sciences, 2024-05, Vol.25 (10), p.5349

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Oocyte-cumulus cell interaction is essential for oocyte maturation and competence. The bidirectional crosstalk network mediated by gap junctions is fundamental for the metabolic cooperation between these cells. As cumulus cells exhibit a more glycolytic phenotype, they can provide metabolic substrates that the oocyte can use to produce ATP via oxidative phosphorylation. The impairment of mitochondrial activity plays a crucial role in ovarian aging and, thus, in fertility, determining the success or failure of assisted reproductive techniques. This review aims to deepen the knowledge about the electro-metabolic coupling of the cumulus-oocyte complex and to hypothesize a putative role of potassium channel modulators in order to improve fertility, promote intracellular Ca influx, and increase the mitochondrial biogenesis and resulting ATP levels in cumulus cells.