Details

Autor(en) / Beteiligte

• Song, Yang
• Hou, Jiangxue
• Wan, Li
• Liu, Kaiqi
• Zhou, Chunlin
• Wei, Shuning
• Zhang, Guangji
• Lin, Dong
• Li, Yan
• Fang, Qiuyun
• Liu, Yuntao
• Gong, Benfa
• Gong, Xiaoyuan
• Wang, Ying
• Wei, Hui
• Wang, Jianxiang
• Mi, Yingchang

Titel

A short report of novel RARG-HNRNPM fusion gene in resembling acute promyelocytic leukemia

Ist Teil von

• Hematology (Luxembourg), 2022-12, Vol.27 (1), p.518-522

Ort / Verlag

England: Taylor & Francis Group

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Resembling acute promyelocytic leukemia (APL) is a unique subtype of APL who sharing clinical, morphological, and immunophenotypic features with typical APL, but lacking evidence of fusion gene and usually insensitive to arsenic trioxide (ATO) and all-trans retinoic acid (ATRA). For years, rearrangement were found in resembling APL continually. The confirmed partner genes of rearrangement included , , , , and . These patients were a group of resembling APL with rare molecular genetic abnormality and unfavorable prognosis. They usually were resistant to ATO and ATRA but partially sensitive to anthracycline-based chemotherapy. We reported a 25-year-old female patient with a novel fusion gene (RARG chr12:53606869: -; chr19: 8527413: + based on GRCh37/hg19 Assembly) through RNA-seq as resembling APL. The patient with was benefited from a combined chemotherapy homoharringtonine, cytarabine, and aclacinomycin (HAA) regimen with no relapse. rearrangement resembling APL are various. The treatment should be switched from ATRA/ATO to AML combined chemotherapy regimen early.