Details

Autor(en) / Beteiligte

• Vollenbrock, Sophie E., MD
• Nowee, Marlies E., MD, PhD
• Voncken, Francine E.M., MD
• Kotte, Alexis N.T.J., PhD
• Goense, Lucas, MD, PhD
• van Rossum, Peter S.N., MD, PhD
• van Lier, Astrid L.H.M.W., PhD
• Heijmink, Stijn W., MD, PhD
• Bartels-Rutten, Annemarieke, MD, PhD
• Wessels, Frank J., MD
• Aleman, Berthe M.P., MD, PhD
• Dewit, Luc, MD, PhD
• Kerkmeijer, Linda G.W., MD, PhD
• Jansen, Edwin P.M., MD, PhD
• Intven, Martijn, MD, PhD
• Lips, Irene M., MD, PhD
• Meijer, Gert J., PhD
• Nijkamp, Jasper, PhD

Titel

Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

Ist Teil von

• Advances in radiation oncology, 2019-10, Vol.4 (4), p.596-604

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• AbstractPurposeCurrent delineation of the gross tumor volume (GTV) in esophageal cancer relies on computed tomography (CT) and combination with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET). There is increasing interest in integrating magnetic resonance imaging (MRI) in radiation treatment, which can potentially obviate CT- or FDG-PET/CT–based delineation. The aim of this study is to evaluate the feasibility of target delineation on T2-weighted (T2W) MRI and T2W including diffusion-weighted MRI (T2W + DW-MRI) compared with current-practice FDG-PET/CT. MethodsTen observers delineated primary esophageal tumor GTVs of 6 patients on FDG-PET/CT, T2W-MRI, and T2W + DW-MRI. GTVs, generalized conformity indices, in-slice delineation variation (root mean square), and standard deviations in the position of the most cranial and caudal delineated slice were calculated.ResultsDelineations on MRI showed smaller GTVs compared with FDG-PET/CT–based delineations. The main variation was seen at the cranial and caudal border. No differences were observed in conformity indices (FDG-PET/CT, 0.68; T2W-MRI, 0.66; T2W + DW-MRI, 0.68) and in-slice variation (root mean square, 0.13 cm on FDG-PET/CT; 0.10 cm on T2W-MRI; 0.14 cm on T2W + DW-MRI). In the 2 tumors involving the gastroesophageal junction, addition of DW-MRI to T2W-MRI significantly decreased caudal border variation.ConclusionsMRI-based target delineation of the esophageal tumor is feasible with interobserver variability comparable to that with FDG-PET/CT, despite limited experience with delineation on MRI. Most variation was seen at cranial-caudal borders, and addition of DW-MRI to T2W-MRI may reduce caudal delineation variation of gastroesophageal junction tumors.