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Macrophages: A communication network linking Porphyromonas gingivalis infection and associated systemic diseases
Ist Teil von
Frontiers in immunology, 2022-07, Vol.13, p.952040-952040
Ort / Verlag
Frontiers Media S.A
Erscheinungsjahr
2022
Quelle
EZB Free E-Journals
Beschreibungen/Notizen
Porphyromonas gingivalis
(
P. gingivalis
) is a Gram-negative anaerobic pathogen that is involved in the pathogenesis of periodontitis and systemic diseases.
P. gingivalis
has recently been detected in rheumatoid arthritis (RA), cardiovascular disease, and tumors, as well as Alzheimer’s disease (AD), and the presence of
P. gingivalis
in these diseases are correlated with poor prognosis. Macrophages are major innate immune cells which modulate immune responses against pathogens, however, multiple bacteria have evolved abilities to evade or even subvert the macrophages’ immune response, in which subsequently promote the diseases’ initiation and progression.
P. gingivalis
as a keystone pathogen of periodontitis has received increasing attention for the onset and development of systemic diseases.
P. gingivalis
induces macrophage polarization and inflammasome activation. It also causes immune response evasion which plays important roles in promoting inflammatory diseases, autoimmune diseases, and tumor development. In this review, we summarize recent discoveries on the interaction of
P. gingivalis
and macrophages in relevant disease development and progression, such as periodontitis, atherosclerosis, RA, AD, and cancers, aiming to provide an in-depth mechanistic understanding of this interaction and potential therapeutic strategies.