Details

Autor(en) / Beteiligte

• de Ramon, Laura
• Guiteras, Jordi
• Guiteras, Roser
• Cruzado, Josep M
• Grinyó, Josep M
• Torras, Juan

Titel

The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response?

Ist Teil von

• International journal of molecular sciences, 2018-04, Vol.19 (5), p.1283

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Costimulatory molecules have been identified as crucial regulators in the inflammatory response in various immunologic disease models. These molecules are classified into four different families depending on their structure. Here, we will focus on various ischemia studies that use costimulatory molecules as a target to reduce the inherent inflammatory status. Furthermore, we will discuss the relevant role of T regulatory cells in these inflammatory mechanisms and the costimulatory pathways in which they are involved.