Details

Autor(en) / Beteiligte

• Li, Tingting
• Han, Xiaojian
• Gu, Chenjian
• Guo, Hangtian
• Zhang, Huajun
• Wang, Yingming
• Hu, Chao
• Wang, Kai
• Liu, Fengjiang
• Luo, Feiyang
• Zhang, Yanan
• Hu, Jie
• Wang, Wang
• Li, Shenglong
• Hao, Yanan
• Shen, Meiying
• Huang, Jingjing
• Long, Yingyi
• Song, Shuyi
• Wu, Ruixin
• Mu, Song
• Chen, Qian
• Gao, Fengxia
• Wang, Jianwei
• Long, Shunhua
• Li, Luo
• Wu, Yang
• Gao, Yan
• Xu, Wei
• Cai, Xia
• Qu, Di
• Zhang, Zherui
• Zhang, Hongqing
• Li, Na
• Gao, Qingzhu
• Zhang, Guiji
• He, Changlong
• Wang, Wei
• Ji, Xiaoyun
• Tang, Ni
• Yuan, Zhenghong
• Xie, Youhua
• Yang, Haitao
• Zhang, Bo
• Huang, Ailong
• Jin, Aishun

Titel

Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

Ist Teil von

• Nature communications, 2021-11, Vol.12 (1), p.6304-6304, Article 6304

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Abstract Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor binding domain (RBD) specific monoclonal antibodies (mAbs), 58G6, 510A5 and 13G9, with high neutralizing potency blocking authentic SARS-CoV-2 virus display remarkable efficacy against authentic B.1.351 virus. Surprisingly, structural analysis has revealed that 58G6 and 13G9 both recognize the steric region S 470–495 on the RBD, overlapping the E484K mutation presented in B.1.351. Also, 58G6 directly binds to another region S 450–458 in the RBD. Significantly, 58G6 and 510A5 both demonstrate prophylactic efficacy against authentic SARS-CoV-2 and B.1.351 viruses in the transgenic mice expressing human ACE2 (hACE2), protecting weight loss and reducing virus loads. Together, we have evidenced 2 potent neutralizing Abs with unique mechanism targeting authentic SARS-CoV-2 mutants, which can be promising candidates to fulfill the urgent needs for the prolonged COVID-19 pandemic.