Details

Autor(en) / Beteiligte

• Clark, Edward G
• Vijayan, Anitha

Titel

Reply to: "Is Prolonged Intermittent Renal Replacement Therapy actually safe for hemodynamically unstable patients?"

Ist Teil von

• Critical care (London, England), 2023-04, Vol.27 (1), p.165-165, Article 165

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• While we acknowledge that renal replacement therapy (RRT) modality comparison studies are fraught with methodologic challenges, a 2021 systematic review of studies involving hemodynamically unstable patients with acute kidney injury (N = 1160, in total) concluded that there was no major advantage to using continuous renal replacement therapy (CRRT) versus SLED [4]. Beyond that, a recent systematic review and network meta-analysis of randomized controlled trials comparing RRT modalities in critically ill patients with acute kidney injury (including five trials comparing CRRT vs SLED [N = 463]) determined that SLED may be the most effective intervention at reducing mortality (albeit with a low certainty of evidence) and, more robustly, that it is non-inferior to CRRT [5]. Comparing renal replacement therapy modalities in critically ill patients with acute kidney injury: a systematic review and network meta-analysis.