Details

Autor(en) / Beteiligte

• Kaufmann, Eva
• Khan, Nargis
• Tran, Kim A.
• Ulndreaj, Antigona
• Pernet, Erwan
• Fontes, Ghislaine
• Lupien, Andréanne
• Desmeules, Patrice
• McIntosh, Fiona
• Abow, Amina
• Moorlag, Simone J.C.F.M.
• Debisarun, Priya
• Mossman, Karen
• Banerjee, Arinjay
• Karo-Atar, Danielle
• Sadeghi, Mina
• Mubareka, Samira
• Vinh, Donald C.
• King, Irah L.
• Robbins, Clinton S.
• Behr, Marcel A.
• Netea, Mihai G.
• Joubert, Philippe
• Divangahi, Maziar

Titel

BCG vaccination provides protection against IAV but not SARS-CoV-2

Ist Teil von

• Cell reports (Cambridge), 2022-03, Vol.38 (10), p.110502-110502, Article 110502

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2022

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Since the vast majority of species solely rely on innate immunity for host defense, it stands to reason that a critical evolutionary trait like immunological memory evolved in this primitive branch of our immune system. There is ample evidence that vaccines such as bacillus Calmette-Guérin (BCG) induce protective innate immune memory responses (trained immunity) against heterologous pathogens. Here we show that while BCG vaccination significantly reduces morbidity and mortality against influenza A virus (IAV), it fails to provide protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In contrast to IAV, SARS-CoV-2 infection leads to unique pulmonary vasculature damage facilitating viral dissemination to other organs, including the bone marrow (BM), a central site for BCG-mediated trained immunity. Finally, monocytes from BCG-vaccinated individuals mount an efficient cytokine response to IAV infection, while this response is minimal following SARS-CoV-2. Collectively, our data suggest that the protective capacity of BCG vaccination is contingent on viral pathogenesis and tissue tropism. [Display omitted] •BCG vaccination provides significant protection against IAV in mice and hamsters•BCG provides no protection against SARS-CoV-2 in mice and hamsters•SARS-CoV-2 induces pulmonary hemorrhage and disseminates to the bone marrow•Monocytes from BCG-vaccinated humans induce more cytokines to IAV than SARS-CoV-2 Kaufmann et al. show that BCG vaccination protects mice and hamsters against influenza, but not SARS-CoV-2. The distinct tropism of SARS-CoV-2 for pulmonary endothelial cells may lead to lung hemorrhage and systemic viral dissemination. Thus, the protection of BCG against viral pathogens is mainly determined by pathogenesis of infections.