Details

Autor(en) / Beteiligte

• Michalkova, Radka
• Kello, Martin
• Cizmarikova, Martina
• Bardelcikova, Annamaria
• Mirossay, Ladislav
• Mojzis, Jan

Titel

Chalcones and Gastrointestinal Cancers: Experimental Evidence

Ist Teil von

• International journal of molecular sciences, 2023-03, Vol.24 (6), p.5964

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers with a high incidence rate worldwide. The current treatment including surgery, chemotherapy or radiotherapy has several limitations such as drug toxicity, cancer recurrence or drug resistance and thus it is a great challenge to discover an effective and safe therapy for CRC and GC. In the last decade, numerous phytochemicals and their synthetic analogs have attracted attention due to their anticancer effect and low organ toxicity. Chalcones, plant-derived polyphenols, received marked attention due to their biological activities as well as for relatively easy structural manipulation and synthesis of new chalcone derivatives. In this study, we discuss the mechanisms by which chalcones in both in vitro and in vivo conditions suppress cancer cell proliferation or cancer formation.