Details

Autor(en) / Beteiligte

• Buchbender, Christian
• Ostendorf, Benedikt
• Mattes-György, Katalin
• Miese, Falk
• Wittsack, Hans-Joerg
• Quentin, Michael
• Specker, Christof
• Schneider, Matthias
• Antoch, Gerald
• Müller, Hans-Wilhelm
• Scherer, Axel

Titel

Synovitis and bone inflammation in early rheumatoid arthritis: high-resolution multi-pinhole SPECT versus MRI

Ist Teil von

• Diagnostic and interventional radiology (Ankara, Turkey), 2013-01, Vol.19 (1), p.20-24

Ort / Verlag

Turkey: Aves Yayincilik Ltd. STI

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• We aimed to assess the relationship between bone inflammation in multi-pinhole single-photon emission computed tomography (MPH-SPECT) and synovitis detected by magnetic resonance imaging (MRI) in early rheumatoid arthritis patients. MPH-SPECT with technetium dicarboxypropanedisphosphonate (Tc-99mDPD) and 3 Tesla MRI were performed in 10 early rheumatoid arthritis patients. Eighty finger joint sites were assessed for increased osteoblastic activity using visual and region-of-interest (ROI) analysis. Presence of joint inflammation in MRI was investigated using the subscores of the rheumatoid arthritis MRI score. Tc-99mDPD uptake was increased in 38 (47.5%) and 22 (27.5%) joint sites as determined by visual and ROI analysis, respectively. A total of 32 (84.2%) sites with increased bone metabolism showed a normal MRI bone signal. The MPH-SPECT uptake ratio was elevated only in the subgroup with severe synovitis (P < 0.001). In early rheumatoid arthritis, molecular imaging with MPH-SPECT detects higher rates of inflammatory bone involvement compared to MRI. Our preliminary data suggest that osteitis is related to severe synovitis.