Details

Autor(en) / Beteiligte

• Iafusco, Fernanda
• Maione, Giovanna
• Rosanio, Francesco Maria
• Mozzillo, Enza
• Franzese, Adriana
• Tinto, Nadia

Titel

Cystic Fibrosis-Related Diabetes (CFRD): Overview of Associated Genetic Factors

Ist Teil von

• Diagnostics (Basel), 2021-03, Vol.11 (3), p.572

Ort / Verlag

Switzerland: MDPI

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population and is caused by mutations in the CF transmembrane conductance regulator ( ) gene that encodes for a chloride/bicarbonate channel expressed on the membrane of epithelial cells of the airways and of the intestine, as well as in cells with exocrine and endocrine functions. A common nonpulmonary complication of CF is cystic fibrosis-related diabetes (CFRD), a distinct form of diabetes due to insulin insufficiency or malfunction secondary to destruction/derangement of pancreatic betacells, as well as to other factors that affect their function. The prevalence of CFRD increases with age, and 40-50% of CF adults develop the disease. Several proposed hypotheses on how CFRD develops have emerged, including exocrine-driven fibrosis and destruction of the entire pancreas, as well as contrasting theories on the direct or indirect impact of mutation on islet function. Among contributors to the development of CFRD, in addition to genotype, there are other genetic factors related and not related to type 2 diabetes. This review presents an overview of the current understanding on genetic factors associated with glucose metabolism abnormalities in CF.