Details

Autor(en) / Beteiligte

• Chiuppesi, Flavia
• Nguyen, Vu H
• Park, Yoonsuh
• Contreras, Heidi
• Karpinski, Veronica
• Faircloth, Katelyn
• Nguyen, Jenny
• Kha, Mindy
• Johnson, Daisy
• Martinez, Joy
• Iniguez, Angelina
• Zhou, Qiao
• Kaltcheva, Teodora
• Frankel, Paul
• Kar, Swagata
• Sharma, Ankur
• Andersen, Hanne
• Lewis, Mark G
• Shostak, Yuriy
• Wussow, Felix
• Diamond, Don J

Titel

Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates

Ist Teil von

• npj vaccines, 2022-01, Vol.7 (1), p.7-7, Article 7

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Second-generation COVID-19 vaccines could contribute to establish protective immunity against SARS-CoV-2 and its emerging variants. We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara-based SARS-CoV-2 vaccine that co-expresses spike and nucleocapsid antigens. Here, we report COH04S1 vaccine efficacy in animal models. We demonstrate that intramuscular or intranasal vaccination of Syrian hamsters with COH04S1 induces robust Th1-biased antigen-specific humoral immunity and cross-neutralizing antibodies (NAb) and protects against weight loss, lower respiratory tract infection, and lung injury following intranasal SARS-CoV-2 challenge. Moreover, we demonstrate that single-dose or two-dose vaccination of non-human primates with COH04S1 induces robust antigen-specific binding antibodies, NAb, and Th1-biased T cells, protects against both upper and lower respiratory tract infection following intranasal/intratracheal SARS-CoV-2 challenge, and triggers potent post-challenge anamnestic antiviral responses. These results demonstrate COH04S1-mediated vaccine protection in animal models through different vaccination routes and dose regimens, complementing ongoing investigation of this multiantigen SARS-CoV-2 vaccine in clinical trials.