Details

Autor(en) / Beteiligte

• Yang, Zhi-Hong
• Gorusupudi, Aruna
• Lydic, Todd A.
• Mondal, Anupam K.
• Sato, Seizo
• Yamazaki, Isao
• Yamaguchi, Hideaki
• Tang, Jingrong
• Rojulpote, Krishna Vamsi
• Lin, Anna B.
• Decot, Hannah
• Koch, Hannah
• Brock, Daniel C.
• Arunkumar, Ranganathan
• Shi, Zhen-Dan
• Yu, Zu-Xi
• Pryor, Milton
• Kun, Julia F.
• Swenson, Rolf E.
• Swaroop, Anand
• Bernstein, Paul S.
• Remaley, Alan T.

Titel

Dietary fish oil enriched in very-long-chain polyunsaturated fatty acid reduces cardiometabolic risk factors and improves retinal function

Ist Teil von

• iScience, 2023-12, Vol.26 (12), p.108411-108411, Article 108411

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Very-long-chain polyunsaturated fatty acids (VLCPUFAs; C24-38) constitute a unique class of PUFA that have important biological roles, but the lack of a suitable dietary source has limited research in this field. We produced an n-3 C24-28-rich VLCPUFA-oil concentrated from fish oil to study its bioavailability and physiological functions in C57BL/6J mice. The serum and retinal C24:5 levels increased significantly compared to control after a single-dose gavage, and VLCPUFAs were incorporated into the liver, brain, and eyes after 8-week supplementation. Dietary VLCPUFAs resulted in favorable cardiometabolic changes, and improved electroretinography responses and visual performance. VLCPUFA supplementation changed the expression of genes involved in PPAR signaling pathways. Further in vitro studies demonstrated that the VLCPUFA-oil and chemically synthesized C24:5 are potent agonists for PPARs. The multiple potential beneficial effects of fish oil-derived VLCPUFAs on cardiometabolic risk and eye health in mice support future efforts to develop VLCPUFA-oil into a supplemental therapy. [Display omitted] •Dietary C24-28-rich VLCPUFAs concentrated from fish oil are bioavailable in mice•Dietary VLCPUFAs are incorporated into the liver, brain, and eyes•VLCPUFA supplement improves cardiometabolic risk factors and retinal function•VLCPUFAs trigger PPAR activation and modulate hepatic gene expression profile Dietary supplement; Physiology; Cell biology