Details

Autor(en) / Beteiligte

• Mills, Logan
• Drymousis, Panagiotis
• Vashist, Yogesh
• Burdelski, Christoph
• Prachalias, Andreas
• Srinivasan, Parthi
• Menon, Krishna
• Cotoi, Corina
• Khan, Saboor
• Cave, Judith
• Armstrong, Thomas
• Weickert, Martin O
• Izbicki, Jakob
• Schrader, Joerg
• Frilling, Andreja
• Ramage, John K
• Srirajaskanthan, Raj

Titel

Tumour diameter is not reliable for management of non-secreting pancreatic neuroendocrine tumours

Ist Teil von

• Endocrine Connections, 2017-11, Vol.6 (8), p.876-885

Ort / Verlag

England: Bioscientifica Ltd

Erscheinungsjahr

2017

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Small non-functioning pancreatic NETs (pNETs) ≤2 cm can pose a management dilemma in terms of surveillance or resection. There is evidence to suggest that a surveillance approach can be considered since there are no significant radiological changes observed in lesions during long-term follow-up. However, other studies have suggested loco-regional spread can be present in ≤2 cm pNETs. The aim of this study was to characterise the prevalence of malignant features and identify any useful predictive variables in a surgically resected cohort of pNETs. 418 patients with pNETs were identified from 5 NET centres. Of these 227 were included for main analysis of tumour characteristics. Mean age of patients was 57 years, 47% were female. The median follow-up was 48.2 months. Malignant features were identified in 38% of ≤2 cm pNETs. ROC analysis showed that the current cut-off of 20 mm had a sensitivity of 84% for malignancy. The rate of malignant features is in keeping with other surgical series and challenges the belief that small pNETs have a low malignant potential. This study does not support a 20 mm size cut-off as being a solitary safe parameter to exclude malignancy in pNETs.