Details

Autor(en) / Beteiligte

• Baumann, Ulrich
• Schulte, Johannes H.
• Groß, Jonathan P.
• Beier, Rita
• Ludwig, Marius
• Wahn, Volker
• Hofmann, Jörg
• Maecker-Kolhoff, Britta
• Sauer, Martin
• Kaiser-Labusch, Petra
• Karimian, Negin
• Blume-Peytavi, Ulrike
• Ghoreschi, Franziska
• Ott, Hagen
• Perelygina, Ludmila
• Klemann, Christian
• Blankenstein, Oliver
• von Bernuth, Horst
• Krüger, Renate

Titel

Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation

Ist Teil von

• Frontiers in immunology, 2022-06, Vol.13

Ort / Verlag

Frontiers Media S.A

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• We report two patients with DNA repair disorders (Artemis deficiency, Ataxia telangiectasia) with destructive skin granulomas, presumably triggered by live-attenuated rubella vaccinations. Both patients showed reduced naïve T cells. Rapid resolution of skin lesions was observed following hematopoietic stem cell transplantation. However, the patient with AT died due to complications of severe hepatic veno-occlusive disease 6 month after HSCT. Dried blood spots obtained after birth were available from this patient and showed absent T-cell receptor excision circles (TRECs). Therefore, newborn screening may help to prevent patients with moderate T-cell deficiency from receiving live-attenuated rubella vaccine potentially causing granulomas.